Homollea is characterized by its woody habit; interpetiolar triangular stipules; petiolate leaves that are generally pubescent and rather thick-textured; terminal, shortly cymose, rounded, sessile to shortly pedunculate inflorescences; bisexual homostylous flowers; the calyx with a well developed tube and 5 usually rather short lobes; salverform to funnelform, usually externallay sericeous to velutinous corollas with the 5 lobes contorted in bud; the ovary ridged and 2-locular, with 3-4 ovules in each locule; and berry-like fruits with the seeds reniform, somewhat flattened, and with entire endosperm. Only one species has been formally described in this genus, but not all the specimens of Homolliella appear to belong to this species.
De Block (2003) noted that this genus is closely related to Paracephaelis and Homollea, although the species of Homollea do not have a very similar general aspect to the species of those genera. Homollea differs in its generally unbranched inflorescences borne on well developed peduncles and its long narrow calyx lobes; Paracephaelis differs in its calyx with the lobes longer than the tube and often shorter flowers. Some species of Homolliella are similar in general aspect to Schizenterospermum, but that last genus has the corolla lobes valvate in bud.