This species is characterized by its medium-sized, rather coriaceous, elliptic to ovate leaves that are generally sharply acute at the apex; its several-flowered, subsessile, congested-cymose inflorescences; its developed calyx limb that is strigose externally and clearly lobed; its medium-sized corollas; its rather small fruits; and its habitat in rather dry vegetation. It is similar to Tricalysia boiviniana, which has the leaves often relatively more narrow and of thicker texture, and the calyx limb subtrucate to very shortly lobed. Tricalysia perrieri has been frequently collected on tsingy limestone substrates. Ranarivelo-Randriamboavonjy et al. (2007) recognized two subspecies that were distinguished by pubescence, with Tricalysia perrieri subsp. perrieri found in north-central Majunga and densely pilosulous in particular on the leaves, corollas, style, and stigmas, vs. a range in southwestern Majunga and the plants glabrescent to strigillose on these structures in Tricalysia perrieri subsp. antsalovensis. Tricalysia perrieri is similar to Tricalysia humbertii, which is found in Antsiranana.